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Several studies have shown that independently
2020-08-12

Several studies have shown that, independently of body-weight control, the central actions of leptin improve glycemic control in obese diabetic rat and mouse models [62]. For instance, restoration of OB-Rb expression in OB-Rb-deficient mice, and in particular in POMC neurons, was sufficient to norma
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A major open question in the field of lipid mediators
2020-08-12

A major open question in the field of lipid mediators is the molecular nature of the PLA2 enzyme involved in the release of DHA and related omega-3 fatty acids from phospholipids as a first committed step for the generation of SPMs. Although by analogy with AA it is often assumed that cPLA2α may ser
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In addition to cleaving ubiquitins off modified proteins
2020-08-11

In addition to cleaving ubiquitins off modified proteins, DUBs can also cleave between ubiquitin moieties within a polyubiquitin chain to edit the ubiquitin signal. DUBs employ different strategies to recognize polyubiquitin (Figure 1). DUBs that rely only on interactions on the S1 site tend to be P
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br Results and discussion A systematic search for
2020-08-11

Results and discussion A systematic search for genes encoding H+-PPases was carried out by PCR using genomic DNA from a wide range of protozoa as templates and degenerate oligonucleotides, designed from amino Colistin Sulfate mg domains conserved in H+-PPases of higher plants and the proteobacte
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br Conclusion br Limitations br Conflict of interest br
2020-08-11

Conclusion Limitations Conflict of interest Financial disclosure The research was supported by National Institute of Mental Health and Neuro Sciences (NIMHANS)Intramural Research Grant ID NIMH/PROJ-RSM/545/2014-15. India. Acknowledgments Introduction Increased central and peripher
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On the basis of the published articles it is
2020-08-11

On the basis of the published articles, it is known that chemokines are produced by leukocytes and tissue cells, constitutively or after induction. Chemokines are responsible for the recruitment of leukocytes to maintain proper functioning of the immune system [14]. They exist in the central nervous
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6015 The second constraint indicates that
2020-08-11

The second constraint indicates that if the relationship between two components A and B is two-way, then there are at least two connectors, one with origin A and destination B, and another connector with origin B and destination A (OCL2 of Fig. 4). Therefore, at least one output port of the first co
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br Materials and methods br Results and discussion
2020-08-11

Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta
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Abbas et al studied the mitigation of ASR
2020-08-11

Abbas et al. studied the mitigation of ASR in their corresponding study by incorporating RHA [1]. These researchers used Ordinary Portland Cement (OPC), four different percentages (i.e., 10%, 20%, 30% and 40% by weight of OPC) of RHA and reactive aggregate (sand from Dolomite-limestone rock) in thei
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br Discussion We are reporting
2020-08-11

Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in varlitinib synthesis exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnorma
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Even minor alterations in the
2020-08-11

Even minor alterations in the surfactants structure could have consequences on their physico-chemical characteristics; mono-RLs have less solubility, stronger surfaces sorb, and stronger cationic metals binding than homologue di-RLs (Zhang et al., 1997). The HPLC separation of RLs structure is base
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br Results br Discussion Fetal development
2020-08-11

Results Discussion Fetal development occurs under conditions of low oxygen tension and steady maternal glucose such that physiologic systems including the pancreas are functionally poised in the prenatal state. Postnatally, oxidative metabolism becomes dominant and intermittent feeding exposes
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br Acknowledgements The study of RING type
2020-08-10

Acknowledgements The study of RING-type E3s continues to grow extremely rapidly. We regret that it was possible to only cite a fraction of the outstanding primary publications in this field. This work was supported by the National Institute of General Medical Sciences grants R01 GM088055 and R01
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The X ray crystal structure of palbociclib bound to
2020-08-10

The X-ray crystal structure of palbociclib bound to CDK6 without a OSI-420 australia (PDB ID: 5L2I) is very similar to that of the CDK6-cyclin V structure (Fig. 7B). However, the drug binds to the αCout conformation of monomeric CDK6 while it binds to the αCin conformation of the CDK6-cyclin V comp
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lipid metabolism Instead of introducing extra hardware or ha
2020-08-10

Instead of introducing extra hardware or hardware modification, software-based CFC techniques just insert extra checking instructions into the source code of the target program at compile time so as to have the target program do checking jobs itself. Preeminent software-based CFC techniques proposed
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