• The aim of our study was to understand the

  2020-08-04

  

  The aim of our study was to understand the role of serum ChE activity in patients with radiation-recurrent CaP who underwent SRP. To this end, we evaluated the association of preoperative serum ChE with clinicopathologic characteristics and outcomes in patients treated with SRP for biochemically rec

• The parent tibolone molecule does not bind to the ER

  2020-08-04

  

  The parent tibolone molecule does not bind to the ER, but estrogenic activity appears after metabolism to the two 3-OH-metabolites by 3α hydroxysteroid dehydrogenase (HSD) and 3β HSD/isomerase in the liver and intestine [17]. Due to the presence of a 3-OH-group in the A-ring of the steroid skeleton

• Chemical cytometry utilizes sensitive analytical techniques

  2020-08-04

  

  Chemical cytometry utilizes sensitive analytical techniques such as microelectrophoresis or mass spectrometry to analyze and characterize the contents of single beta lapachone (Dovichi, 2010; Dovichi & Hu, 2003). Microelectrophoretic chemical cytometry is well-suited to address many of the challeng

• Celiac disease occurs in the small

  2020-08-04

  

  Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they

• Some E s have been

  2020-08-04

  

  Some E2s have been shown to bind to co-factors that can alter the activity or subcellular localization of the recruited E2 [28]. One example is the CUE1 co-factor which recruits the cytoplasmic UBC7 (UBE2G2) E2 enzyme to the endoplasmic reticulum (ER) where it participates in the degradation of misf

• E is a classical initiator protein and as such plays

  2020-08-04

  

  E1 is a classical initiator protein and, as such, plays several roles in the initiation and catalysis of viral DNA synthesis. E1 must first recognize a specific segment of the viral rgd peptide known as the “origin of DNA replication”, or “ori” for short. For most PV types examined to date, the mini

• BrdU IP ssSeq revealed that late replication origins fired i

  2020-08-04

  

  BrdU-IP-ssSeq revealed that late replication origins fired in the presence of HU in rad53-1 mutant BG45 (Figure 1B), consistent with published studies (Santocanale and Diffley, 1998). Remarkably, BrdU-IP-ssSeq peaks in rad53-1 cells were asymmetrically distributed and showed a strong bias toward lag

• PD173955 br Materials and methods br Results br Discussion P

  2020-08-04

  

  Materials and methods Results Discussion Previously, we reported the identification of a mutation, G469E, in a LIG4 syndrome patient which severely impacts upon DNA ligase IV function [5]. Closer examination of the sequence in the vicinity of G469 revealed a motif, designated Va, that is w

• br Results br Discussion In

  2020-08-03

  

  Results Discussion In this study, we elucidate how cell-secreted, soluble ECDs of DDR1 and DDR2 inhibit collagen fibrillogenesis and enhance matrix mineralization for ECM endogenously generated by the cells. Using similar experimental approaches, in our earlier work we had demonstrated that ki

• br Experimental procedures br Introduction Protein kinases r

  2020-08-03

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme Levonorgestrel in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity, tar

• High density of CRF containing terminals arising mainly

  2020-08-03

  

  High density of CRF-containing terminals, arising mainly from the central nucleus of the amygdala [20], [21], and moderate to dense Ucn1- and Ucn3-immunoreactive fibers [22], [23] were found within BNST. Also, populations of CRF- and Ucn3-containing neurons have been identified in the BNST [23], [24

• PEGylation can be combined with other strategies to improve

  2020-08-03

  

  PEGylation can be combined with other strategies to improve drug delivery. For example, it has been used in conjunction with niosomes, i.e. non-ionic surfactant-based vesicles that can carry various drugs within them, to improve cell targeting. Niosomes are first rendered magnetic with Fe3O4@SiO2 na

• The biocontrol agent BCA Bacillus

  2020-08-03

  

  The biocontrol agent (BCA) Bacillus amyloliquefaciens CPA-8, formerly known as Bacillus subtilis (Gotor-Vila et al., 2016) has been reported as an effective antagonist against brown rot caused by Monilinia spp. (Casals et al., 2012; Gotor-Vila et al., 2017a; Yánez-Mendizábal et al., 2011), the wound

• myosin br Conclusions and future work Our approach

  2020-08-03

  

  Conclusions and future work Our approach proposes the use of another DSL to specify components. Thus, the possible application domains are restricted to those software architectures built from components that meet our component definition. We call our type of component COTSget, from the combinati

• It is also observed that

  2020-08-03

  

  It is also observed that the increase in the area due to mitigation was proportionally smaller for the ProASIC FPGA. The reason can be attributed to a different resource utilization optimization because of the FPGA\'s internal architecture (ProASICs are based on more versatile logic cells). To empha

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