• We report our experience using conventional

  2020-03-17

  

  We report our experience using conventional cytogenetic analysis, FISH using EWSR1 break-apart probes, RT-PCR, and Sanger sequencing to detect characteristic translocations in a total of 32 patients with ES diagnosed at Texas Children\'s Hospital over a 5-year interval. Materials and methods R

• The idea that ASB can drive compartment expansion in

  2020-03-17

  

  The idea that ASB11 can drive compartment expansion in the CNS is further supported by in vitro work in human neuronal precursors. Nerve growth factor (NGF)-induced differentiation of PC12 pheochromocytoma Griseofulvin australia [11] and RA-induced human pluripotent teratocarcinoma carcinoma (NT2)

• COH inhibited global SUMOylation in

  2020-03-17

  

  COH000 inhibited global SUMOylation in Cy5 TSA and blocked the E1 catalyzed attachment of SUMO to the corresponding conjugating enzyme Ubc9, but not the attachment of ubiquitin or NEDD8 to their respective E2s, confirming inhibition and specificity in cellulo. Consistent with previous studies inact

• Interestingly all three lesions that significantly inhibited

  2020-03-17

  

  Interestingly, all three lesions that significantly inhibited transcription – CPD, εA and the AP site, – promoted insertion of BGB324 residues opposite the damaged nucleotide. Thus, bacterial RNAP seems to follow the so-called ‘A-rule’ for incorporation of nucleotides opposite AP-sites and bulky le

• Db model cells showed various aberrant phenotypes that

  2020-03-17

  

  Db model cells showed various aberrant phenotypes that seemed to reflect the pathological abnormalities found under diabetic conditions. First, in Db model cells after insulin stimulation, we found the inhibition of the transcriptional repression of the gluconeogenic genes, PCK1 and G6PC, and aberra

• Although the formation and toxicity of DPC is theoretically

  2020-03-17

  

  Although the formation and toxicity of DPC is theoretically acceptable, it is difficult to evaluate the specific role of DPC and its repair enzyme MGMT in the cytotoxic and mutagenic effects because DPCs are estimated to constitute only 1%–3% of total DNA damage when silibinin are exposed to bis-ele

• DGK is highly expressed in skeletal

  2020-03-17

  

  DGKδ is highly expressed in skeletal muscle [7], which is a primary target of insulin for glucose disposal [14]. Notably, Chibalin et al. reported that DGKδ contributes to hyperglycemia-induced peripheral insulin resistance and that decreased protein levels of DGKδ in skeletal muscle attenuated gluc

• AEBSF HEK cells stably transfected with CysLT were

  2020-03-16

  

  HEK-293 AEBSF stably transfected with CysLT1 were stimulated with LTD and internalization was studied by confocal microscopy, FACS or cell-surface ELISA. Cells were co-transfected with wildtype and dominant negative (DN) mutants of arrestin and dynamin. Clathrin-mediated endocytosis was investigat

• depsipeptide Among RAS mutant tumors analyzed we found that

  2020-03-16

  

  Among RAS mutant tumors analyzed, we found that the efficacy of either the SHP2 inhibitor SHP099, or combined MEK and SHP2 inhibition was best in those expressing RAS mutations at G12 (Figure 7B). Recent studies revealed that cellular RAS(G12C) activity depends on RTK-mediated nucleotide exchange, a

• R-848 receptor Introduction PGE is a major mediator present

  2020-03-16

  

  Introduction PGE2 is a major mediator present at sites of inflammation [1]. It is well established that PGE2 contributes to the localized and systemic symptoms of inflammation. A key study by Portanova et al. [2] demonstrated that anti-PGE2 R-848 receptor were able to reverse the swelling and pain

• More than thirty enzymes with PLA activity have been describ

  2020-03-16

  

  More than thirty enzymes with PLA2 activity have been described and, based on sequence similarities, they are currently classified in 16 groups, each containing several sub-groups [16]. However, based on biochemical features these enzymes are frequently grouped into six major families: secreted phos

• Abdominal aortic aneurysm AAA is considered a major health

  2020-03-16

  

  Abdominal aortic aneurysm (AAA) is considered a major health concern and is associated with extremely high rates of mortality in case of aortic rupture. The main pathophysiologic mechanisms leading to aortic dilation include the degradation of the extracellular matrix (ECM) components, such as colla

• Numerous studies have investigated the contribution

  2020-03-16

  

  Numerous studies have investigated the contribution of N-cadherin to metastasis and tumorigenesis. The overexpression of N-cadherin has been shown to enhance tumor invasion and motility in multiple cancer models [25,40,48]. Transforming growth factor beta 1 (TGFβ1) is a strong EMT inducer. In fact,

• br EBV Infection Epstein Barr virus

  2020-03-16

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T

• While a number of studies have helped elucidate the

  2020-03-16

  

  While a number of studies have helped elucidate the principles of target amino group specificity, UBL selectivity, and Ub (+)-Usniacin specificity [3], [4], [9], [10], [14], [19], [20], [23], [24], [33], [34], [37], [38], [39], [40], [41], the role of the canonical E2-RING interface in governing sub

9998 records 567/667 page Previous Next First page 上5页 566567568569570 下5页 Last page