• ATP is essential for maintaining the ionic balance of the

  2022-08-29

  

  ATP is essential for maintaining the ionic balance of the lens (Michael and Bron, 2011). Without sufficient ATP there is an ionic imbalance due to Na+K+ATPase dysfunction. Previous studies have shown that rabbit lenses incubated ex vivo without glucose rapidly lost ATP in their lens epithelium and f

• Regarding the causative diseases of ES patients with unknown

  2022-08-29

  

  Regarding the causative diseases of ES, patients with unknown cause and those with encephalitis had significantly higher CSF levels of TCS JNK 5a against GluN2B-NT2 and GluN2B-CT than the disease controls, but patients with genetic disorder and those with cortical dysplasia showed no significant dif

• A number of GCK activators for treating

  2022-08-29

  

  A number of GCK activators for treating T2D have been developed and tested but not progressed successfully from clinical trials into therapy [45]. Our observations suggest that increased risk of hypoglycemia might be possible, particularly if drugs penetrate into brain. A further possibility is that

• Regulation of pancreatic and cell mass has been extensively

  2022-08-29

  

  Regulation of pancreatic α and β cell mass has been extensively studied and hotly debated, due to potential therapeutic implications. Early claims of Angptl8 as “betatrophin” and Angptl4 as a regulator of glucagon secretion and α cell proliferation (Yi et al., 2013, Ben-Zvi et al., 2015) have not st

• br Clinical trials testing GLP mimetics in

  2022-08-29

  

  Clinical trials testing GLP-1 mimetics in AD or PD patients GIP analogues show good neuroprotective effects in animal models of AD and PD Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino autophagy inhibitor incretin growth factor which activates pancreatic islets to enhance in

• Subsequently we decided to test whether the orexin pathway

  2022-08-29

  

  Subsequently, we decided to test whether the orexin pathway was involved (Delhanty et al, 2012, Delhanty et al, 2013, Pei et al, 2014). Orexin neuronal systems are known to control limbic and neocortical structures (Bonnavion, de Lecea, 2010, Sakurai, 2007). Orexin receptors and possibly orexin synt

• Sensitivity to EphB TKI was also demonstrated in a

  2022-08-29

  

  Sensitivity to EphB3 TKI was also demonstrated in a colon cancer cell line, COLO 205, with high expression of EphB3. We found not only exogenous but also endogenous EphB3 protein was expressed in the COLO 205 SR 11302 after transient transfection of pCMV6-AC-GFP/EphB3, and both were demonstrated to

• In conclusion a novel series of

  2022-08-29

  

  In conclusion, a novel series of GPR40 agonists containing nitrogen heterocyclic rings derived from TAK-875 were designed and synthesized. The structural activity relationship studies indicated that the substituents on the nitrogen RN486 had a remarkable effect on the GPR40 agonistic activity. Comp

• We identified three genes KEAP NAA and ABCC MRP as

  2022-08-29

  

  We identified three genes—KEAP1, NAA38, and ABCC1/MRP1—as negative regulators of glutathione abundance in human cells. Like KEAP1, NAA38 appears to regulate NRF2 stability, as NAA38 deletion increased NRF2 protein levels and the expression of NRF2 target genes. NAA38 is a component of the NatC N-ter

• The current lack of effective treatments for primary

  2022-08-27

  

  The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th

• The current lack of effective treatments for primary

  2022-08-27

  

  The current lack of effective treatments for primary or metastatic UM leaves a large therapeutic gap for patients and clinicians underscoring an urgent need for the identification of additional pharmacological targets for therapeutic intervention. As YAP-targeting strategies have remained elusive th

• Lovastatin br Materials and methods br Results br Discussion

  2022-08-27

  

  Materials and methods Results Discussion The development of HCC is a multistep process involving the accumulation of multiple genetic and epigenetic alterations that lead to the activation of oncogenes and inactivation of tumor suppressor genes [20]. Frequent intrahepatic or pulmonary metas

• Lovastatin br Materials and methods br Results br Discussion

  2022-08-27

  

  Materials and methods Results Discussion The development of HCC is a multistep process involving the accumulation of multiple genetic and epigenetic alterations that lead to the activation of oncogenes and inactivation of tumor suppressor genes [20]. Frequent intrahepatic or pulmonary metas

• br Nanoscale Cortical Actin Remodeling in Regulated

  2022-08-27

  

  Nanoscale Cortical Actin Remodeling in Regulated Exocytosis The network of cortical SAG is formed by numerous fine actin filaments, which are only about 10nm in diameter [52]. Although the microscale role of the cortical actin network in vesicle exocytosis is well established, the function of th

• Flutamide Two typical properties of Gi o protein coupled rec

  2022-08-26

  

  Two typical properties of Gi/o protein-coupled receptors, namely an increase in 35S-GTPγS binding (Strange, 2010) and an inhibition of exocytotic noradrenaline release (Schlicker and Göthert, 1998), were not shared by H4 receptor activation on cortical membranes (guinea-pig and mouse) and cortical s

9998 records 79/667 page Previous Next First page 上5页 7677787980 下5页 Last page